Article
Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations.
PloS one - 1 Jan 2015
Deniger Drew C, Yu Jianqiang, Huls M Helen, Figliola Matthew J, Mi Tiejuan, Maiti Sourindra N, Widhopf George F, Hurton Lenka V, Thokala Radhika, Singh Harjeet, Olivares Simon, Champlin Richard E, Wierda William G, Kipps Thomas J, Cooper Laurence J N
Abstract excerpt
T cells modified with chimeric antigen receptors (CARs) targeting CD19 demonstrated clinical activity against some B-cell malignancies. However, this is often accompanied by a loss of normal CD19+ B cells and humoral immunity. Receptor tyrosine kinase-like orphan receptor-1 (ROR1) is expressed on sub-populations of B-cell malignancies and solid tumors, but not by healthy B cells or normal post-partum tissues....
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