Article

HSD17B13 Couples Hepatocyte Lipid Metabolism to Stellate Cell Activation via TGFb-1 Signaling

2025-10-14

Abstract excerpt

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease driven by hepatocellular lipid overload, immune activation, and hepatic stellate cell (HSC)-driven fibrogenesis. Human genetic studies reveal that loss-of-function (LoF) variants in 17 beta-hydroxysteroid dehydrogenase 13 ( HSD17B13 ) confer robust protection against advanced fibrosis and cirrhosis, establishing HSD17B13 as a...

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Literature Corpus work: 87095a6e-449f-5eb7-bd93-93c05a36445f
DOI: 10.1101/2025.10.14.682191

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