Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smad4 restricts injury-provoked biliary proliferation and carcinogenesis

28 Feb 2024

Abstract excerpt

Cholangiocarcinoma (CCA) is a deadly and heterogeneous type of cancer characterized by a spectrum of epidemiologic associations as well as genetic and epigenetic alterations. We seek to understand how these features inter-relate in the earliest phase of cancer development and through the course of disease progression. For this, we studied murine models of liver injury integrating the most commonly occurring gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Pancreatic and Hepatic Oncology Research
Share to Pediatric Hepatobiliary Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38415925
DOI: 10.1242/dmm.050358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smad4 restricts injury-provoked biliary proliferation and carcinogenesisPMID 38415925Read ↗

Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma.Semantic proximity Read ↗

A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin‐4 in Tumor ProgressionSemantic proximity Read ↗

A novel mouse model of cholangiocarcinoma uncovers a role for a SOX17-Tensin 4 pathway in tumor progressionSemantic proximity Read ↗

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.Semantic proximity Read ↗

Genetic, Epigenetic, and Microenvironmental Drivers of Cholangiocarcinoma.Semantic proximity Read ↗

Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistanceSemantic proximity Read ↗

The role of TGF-β/SMAD4 signaling in cancer.Semantic proximity Read ↗

Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in CholangiocarcinomaSemantic proximity Read ↗

Smad4-mediated TGF-β signaling in tumorigenesisSemantic proximity Read ↗

Cholangiocarcinoma: molecular pathways and therapeutic opportunities.Semantic proximity Read ↗

Molecular pathogenesis of intrahepatic cholangiocarcinomaSemantic proximity Read ↗

Molecular Targets in Hepatocarcinogenesis and Implications for TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.