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Article

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function

2025-06-05

Abstract excerpt

Liver progenitor cells (LPCs) are the smallest cholangiocytes that perform hepatocyte functions to rescue the lives of patients suffering from acute liver failure (ALF) caused by massive hepatic necrosis (MHN). To date, it remains largely unknown how LPCs remain quiescent and become activated following MHN. This study elucidates the essential role of TGF-β in regulating LPC quiescence and activation. Spatial trans...

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Literature Corpus work
afa43ff7-ad0e-596e-848e-4c1bdeb0f8a1
DOI
10.1101/2025.06.04.657336
Open publication

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TGF-β serves as a critical signaling determinant of liver progenitor cell fate and functionDOI 10.1101/2025.06.04.657336
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