Article

Virulence Reduction in<em> Yersinia pestis </em>by Combining Delayed Attenuation with Plasmid Curing

2025-12-09

Abstract excerpt

<h4>Background: </h4> /Objectives: Yersinia pestis caused the three plague pandemics that claimed more than two hundred million human lives. There is still no vaccine that meets all WHO requirements, and many researchers continue to develop plague vaccines using various technological platforms. For example, researchers led by Roy Curtiss 3rd have developed a new approach to achieve controlled, delayed attenuation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48090320-9de6-596a-af6e-6742eb342ef6
DOI: 10.20944/preprints202512.0816.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Virulence Reduction in<em> Yersinia pestis </em>by Combining Delayed Attenuation with Plasmid CuringDOI 10.20944/preprints202512.0816.v1Read

Phage therapy potentiates second-line antibiotic treatment against pneumonic plagueSemantic proximity Read

YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected].Semantic proximity Read

Live-attenuated Salmonella enterica serotype Choleraesuis vaccine with regulated delayed fur mutation confer protection against Streptococcus suis in mice.Semantic proximity Read

Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague.Semantic proximity Read

Salmonella enterica serovar typhimurium strains with regulated delayed attenuation in vivo.Semantic proximity Read

Combinatorial viral vector-based and live-attenuated vaccines without an adjuvant to generate broader immune responses to effectively combat pneumonic plagueSemantic proximity Read

Intramuscular Immunization of Mice with a Live-Attenuated Triple Mutant of Yersinia pestis CO92 Induces Robust Humoral and Cell-Mediated Immunity To Completely Protect Animals against Pneumonic Plague.Semantic proximity Read

Bacteriophage-resistant mutants in Yersinia pestis: identification of phage receptors and attenuation for mice.Semantic proximity Read

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.Semantic proximity Read

Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation.Semantic proximity Read

Attenuation and immunogenicity of Deltacya Deltacrp derivatives of Salmonella choleraesuis in pigs.Semantic proximity Read

Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates.Semantic proximity Read