Article

Combinatorial viral vector-based and live-attenuated vaccines without an adjuvant to generate broader immune responses to effectively combat pneumonic plague

2021-10-29

Abstract excerpt

Mice immunized with a combination of an adenovirus vector (Ad5-YFV) and live-attenuated (LMA)-based vaccines were evaluated for protective efficacy against pneumonic plague. While the Ad5-YFV vaccine harbors a fusion cassette of three genes encoding Y scF, F 1, and L crV, LMA represents a mutant of parental Yersinia pestis CO92 deleted for genes encoding L pp, M sbB, and A il. Ad5-YFV and LMA were either ad...

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Literature Corpus work: 4cd6baff-aa54-59dc-aaf0-62cc8186edd7
DOI: 10.1101/2021.10.28.466384

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