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Salmonella enterica serovar typhimurium strains with regulated delayed attenuation in vivo.

Infection and immunity - 1 Mar 2009

Curtiss Roy, Wanda Soo-Young, Gunn Bronwyn M, Zhang Xin, Tinge Steven A, Ananthnarayan Vidya, Mo Hua, Wang Shifeng, Kong Wei

Abstract excerpt

Recombinant bacterial vaccines must be fully attenuated for animal or human hosts to avoid inducing disease symptoms while exhibiting a high degree of immunogenicity. Unfortunately, many well-studied means for attenuating Salmonella render strains more susceptible to host defense stresses encountered following oral vaccination than wild-type virulent strains and/or impair their ability to effectively colonize the...

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Identifiers

PMID: 19103774
DOI: 10.1128/IAI.00693-08
PMCID: PMC2643627

Genes

BAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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