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Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies

27 Mar 2023

Abstract excerpt

Human noroviruses are highly contagious and a major problem in closed institutions, such as schools, hospitals, and cruise ships. Reducing norovirus infections is challenging on multiple levels and includes the frequent emergence of antigenic variants, which complicates designing effective, broadly reactive capsid therapeutics. We successfully developed and characterized four norovirus nanobodies that bound at...

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PMID: 36971561
DOI: 10.1128/jvi.01833-22

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