Article
Multiple antigenic sites are involved in blocking the interaction of GII.4 norovirus capsid with ABH histo-blood group antigens.
Journal of virology - 1 Jul 2012
Parra Gabriel I, Abente Eugenio J, Sandoval-Jaime Carlos, Sosnovtsev Stanislav V, Bok Karin, Green Kim Y
Abstract excerpt
Noroviruses are major etiological agents of acute viral gastroenteritis. In 2002, a GII.4 variant (Farmington Hills cluster) spread so rapidly in the human population that it predominated worldwide and displaced previous GII.4 strains. We developed and characterized a panel of six monoclonal antibodies (MAbs) directed against the capsid protein of a Farmington Hills-like GII.4 norovirus strain that was associated...
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