Article

Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain

2024-03-07

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondria and lysosomes are two organelles that carry out both signaling and metabolic roles in the cells. Recent evidence has shown that mitochondria and lysosomes are dependent on one another, as primary defects in one cause secondary defects in the other. Nevertheless, the signaling consequences of primary mitochondrial malfunction and of primary lysosomal defects are not similar, despite...

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Literature Corpus work: 47fb3455-9118-58a9-857c-d910ecab5b09
DOI: 10.1101/2024.03.06.583589

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