Article

A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

2020-08-31

Abstract excerpt

Somatic cells age and die, but the germ-cell lineage is immortal. In C. elegans , germline immortality involves proteostasis renewal at the beginning of each new generation, when oocyte-maturation signals from sperm trigger the clearance of carbonylated proteins and protein aggregates. Here, we explore the cell biology of this proteostasis renewal in the context of a whole-genome RNAi screen. Oocyte maturation si...

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Literature Corpus work: f7acfb04-2dfe-51e3-9d51-4077a1ef5315
DOI: 10.1101/2020.08.31.276006

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