Article
A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing.
Developmental cell - 20 Jun 2016
Danielsen E Thomas, Moeller Morten E, Yamanaka Naoki, Ou Qiuxiang, Laursen Janne M, Soenderholm Caecilie, Zhuo Ran, Phelps Brian, Tang Kevin, Zeng Jie, Kondo Shu, Nielsen Christian H, Harvald Eva B, Faergeman Nils J, Haley Macy J, O'Connor Kyle A, King-Jones Kirst, O'Connor Michael B, Rewitz Kim F
Abstract excerpt
Steroid hormones control important developmental processes and are linked to many diseases. To systematically identify genes and pathways required for steroid production, we performed a Drosophila genome-wide in vivo RNAi screen and identified 1,906 genes with potential roles in steroidogenesis and developmental timing. Here, we use our screen as a resource to identify mechanisms regulating intracellular levels...
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