Article
Caenorhabditis elegans as a model for lysosomal storage disorders.
Biochimica et biophysica acta - 1 Jan 2000
de Voer Gert, Peters Dorien, Taschner Peter E M
Abstract excerpt
The nematode Caenorhabditis elegans is the simplest animal model available to study human disease. In this review, the worm homologues for the 58 human genes involved in lysosomal storage disorders and for 105 human genes associated with lysosomal function have been compiled. Most human genes had at least one worm homologue. In addition, the phenotypes of 147 mutants, in which these genes have been disrupted or...
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