Article

Lysosomal activity regulates <i>Caenorhabditis elegans</i> mitochondrial dynamics through vitamin B12 metabolism

2020-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial fission and fusion are highly regulated by energy demand and physiological conditions to control the production, activity, and movement of these organelles. Mitochondria are arrayed in a periodic pattern in Caenorhabditis elegans muscle, but this pattern is disrupted by mutations in the mitochondrial fission component dynamin. Here we show that the dramatically disorganized mitoch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c95daa07-ced1-5946-aab9-7d2f983da4ec
DOI: 10.1101/2020.04.20.049502

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysosomal activity regulates <i>Caenorhabditis elegans</i> mitochondrial dynamics through vitamin B12 metabolismDOI 10.1101/2020.04.20.049502Read

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism.Semantic proximity Read

Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chainSemantic proximity Read

Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagySemantic proximity Read

Biochemistry, function, and deficiency of vitamin B <sub>12</sub> in <i>Caenorhabditis elegans</i>Semantic proximity Read

Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signalingSemantic proximity Read

Lysosomes Signal through Epigenome to Regulate Longevity across GenerationsSemantic proximity Read

Autophagy compensates for defects in mitochondrial dynamicsSemantic proximity Read

Modeling human peroxisome biogenesis disorders in the nematode<i>Caenorhabditis elegans</i>Semantic proximity Read

Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans.Semantic proximity Read

Metformin extends C. elegans lifespan through lysosomal pathwaySemantic proximity Read

Adenylosuccinate Lyase activity in the Purine recycling pathway is essential for developmental timing, germline maintenance and muscle integrity in <i>C. elegans</i>Semantic proximity Read

Mitochondrial fragmentation leads to intracellular acidification in Caenorhabditis elegans and mammalian cells.Semantic proximity Read