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Disorders of Lysosome-Related Organelle Biogenesis: Clinical and Molecular Genetics

10 Jun 2008

Abstract excerpt

Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share various features with lysosomes, but are distinct in function, morphology, and composition. The biogenesis of LROs employs a common machinery, and genetic defects in this machinery can affect all LROs or only an individual LRO, resulting in a variety of clinical features. In this review, we discuss the main components of LRO...

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PMID: 18544035
DOI: 10.1146/annurev.genom.9.081307.164303

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