Article
A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans.
G3 (Bethesda, Md.) - 9 Aug 2016
Li Shiwei, Xu Shibin, Ma Yanli, Wu Shuang, Feng Yu, Cui Qingpo, Chen Lifeng, Zhou Shuang, Kong Yuanyuan, Zhang Xiaoyu, Yu Jialei, Wu Mengdi, Zhang Shaobing O
Abstract excerpt
To identify genes that regulate the dynamics of lipid droplet (LD) size, we have used the genetically tractable model organism Caenorhabditis elegans, whose wild-type LD population displays a steady state of size with an upper limit of 3 μm in diameter. From a saturated forward genetic screen of 6.7 × 10(5) mutagenized haploid genomes, we isolated 118 mutants with supersized intestinal LDs often reaching 10 μm....
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