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Personalized tumor combination therapy optimization using the single-cell transcriptome

1 Dec 2023

Abstract excerpt

BACKGROUND: The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for successful personalized cancer treatment. However, the cancer treatment response is often characterized by in vitro assays or bulk transcriptomes that neglect the heterogeneity of malignant tumors in vivo and the immune microenvironment, motivating the need...

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PMID: 38041202
DOI: 10.1186/s13073-023-01256-6

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