Local generation and efficient evaluation of numerous drug combinations in a single sample.

Abstract excerpt

We develop a method that allows one to test a large number of drug combinations in a single-cell culture sample. We rely on the randomness of drug uptake in individual cells as a tool to create and encode drug treatment regimens. A single sample containing thousands of cells is treated with a combination of fluorescently barcoded drugs. We create independent transient drug gradients across the cell culture sample...

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