Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.

doi:10.1038/s41467-020-17440-w

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Article

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.

Nature communications - 27 Aug 2020

McFarland James M, Paolella Brenton R, Warren Allison, Geiger-Schuller Kathryn, Shibue Tsukasa, Rothberg Michael, Kuksenko Olena, Colgan William N, Jones Andrew, Chambers Emily, Dionne Danielle, Bender Samantha, Wolpin Brian M, Ghandi Mahmoud, Tirosh Itay, Rozenblatt-Rosen Orit, Roth Jennifer A, Golub Todd R, Regev Aviv, Aguirre Andrew J, Vazquez Francisca, Tsherniak Aviad

Abstract excerpt

Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate. Information-rich assays, such as gene-expression profiling, have generally not permitted efficient profiling of a given perturbation across multiple cellular contexts. Here, we develop MIX-Seq, a method for multiplexed transcriptional profiling of...

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Identifiers

PMID: 32855387
DOI: 10.1038/s41467-020-17440-w
PMCID: PMC7453022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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