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Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens

25 Oct 2018

Abstract excerpt

Serial tissue sampling has become essential in guiding modern targeted and personalized cancer treatments. An alternative to image guided core biopsies are fine needle aspirates (FNA) that yield cells rather than tissues but are much better tolerated and have lower complication rates. The efficient pathway analysis of such cells in the clinic has been difficult, time consuming and costly. Here we develop an...

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PMID: 30382095
DOI: 10.1038/s41467-018-07002-6

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