Article

<i>Runx1</i> and <i>Runx2</i> act in concert to suppress <i>Wnt/β-catenin</i> -driven mammary tumourigenesis

2025-03-17

Abstract excerpt

<h4>ABSTRACT</h4> The genes encoding transcription factor RUNX1 and its binding partner CBFB have been reported to be mutated in human breast cancer. Here, we provide evidence that Runx1 loss of function results in accelerated disease onset and tumour development in mouse models of breast cancer, in keeping with a tumour suppressor role for RUNX1 in this disease setting. Combined deletion of Runx1 and the rel...

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Literature Corpus work: 47f381d2-606e-54b3-9a7f-fcabd30b3d3c
DOI: 10.1101/2025.03.16.643517

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