Article

RUNX1-deficiency drives immune-active ER <sup>+</sup> mammary tumorigenesis through activation of interferon signaling

2026-04-09

Abstract excerpt

<h4> Abstract </h4> Recurrent loss-of-function mutations in RUNX1 occur in estrogen receptor-positive (ER + ) breast cancers, yet how RUNX1-loss contributes to breast tumorigenesis remains unclear. Here we used genetically engineered mouse models with luminal mammary epithelial cell (MEC)-restricted gene disruption to investigate its role in breast cancer initiation. Loss of RUNX1 alone, or together with RB1,...

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Literature Corpus work: f184417a-f529-554a-ae88-aaf1bc25312f
DOI: 10.64898/2026.04.06.716728

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