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Article

RUNX2 in subtype specific breast cancer and mammary gland differentiation

1 Jan 2014

Abstract excerpt

RUNX2, a master regulator of osteogenesis, is oncogenic in the lymphoid lineage; however, little is known about its role in epithelial cancers. Upregulation of RUNX2 in cell lines correlates with increased invasiveness and the capacity to form osteolytic disease in models of breast and prostate cancer. However, most studies have analysed the effects of this gene in a limited number of cell lines and its role in...

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PMID: 24626992
DOI: 10.1242/dmm.015040

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