Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RUNX transcription factors at the interface of stem cells and cancer.

The Biochemical journal - 10 May 2017

Deltcheva Elitza, Nimmo Rachael

Abstract excerpt

The RUNX1 transcription factor is a critical regulator of normal haematopoiesis and its functional disruption by point mutations, deletions or translocations is a major causative factor leading to leukaemia. In the majority of cases, genetic changes in RUNX1 are linked to loss of function classifying it broadly as a tumour suppressor. Despite this, several recent studies have reported the need for a certain level...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Differentiation
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasm Proteins

Share to Neoplasms

Share to Stem Cells

Source

Identifiers

PMID: 28490659
DOI: 10.1042/BCJ20160632

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RUNX transcription factors at the interface of stem cells and cancer.PMID 28490659Read ↗

New insights into the role of Runx1 in epithelial stem cell biology and pathologySemantic proximity Read ↗

RUNX genes find a niche in stem cell biologySemantic proximity Read ↗

Normal and transforming functions of RUNX1: A perspectiveSemantic proximity Read ↗

Defining a tissue stem cell‐driven Runx1/Stat3 signalling axis in epithelial cancerSemantic proximity Read ↗

RUNX3 in Stem Cell and Cancer Biology.Semantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

RUNX1 and cancerSemantic proximity Read ↗

Runx2 in normal tissues and cancer cells: A developing storySemantic proximity Read ↗

The RUNX genes: gain or loss of function in cancer.Semantic proximity Read ↗

Role of RUNX1 in hematological malignanciesSemantic proximity Read ↗

RUNX family: Regulation and diversification of roles through interacting proteins.Semantic proximity Read ↗

The RUNX Family, a Novel Multifaceted Guardian of the GenomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.