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Animal models for chronic lymphocytic leukemia

27 Nov 2006

Abstract excerpt

B-cell chronic lymphocytic leukemia (B-CLL), the most common leukemia in the Western world, results from an expansion of a rare population of CD5+ mature B-lymphocytes. Although clinical features and genomic abnormalities in B-CLL have been studied in considerable detail, the molecular mechanisms underlying disease development has remained unclear until recently. In the last 4 years, several transgenic mouse...

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PMID: 17131382
DOI: 10.1002/jcb.21147

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