Article

Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular source

2025-02-27

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is broadly produced by various cell types, particularly immune cells, and functions as a key modulator of innate and adaptive immunity. Increasing evidence has linked MIF to the pathogenesis of both solid tumors and hematologic malignancies, including chronic lymphocytic leukemia (CLL). We previously showed that the global deletion of Mif in the TCL1 transgenic mouse m...

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Literature Corpus work: be1a366e-81e3-5bb8-84e9-67cf2ce8fd08
DOI: 10.1101/2025.02.22.639632

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