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CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia

1 Apr 2013

Abstract excerpt

The cell-surface glycoprotein CD44 is expressed in chronic lymphocytic leukemia (CLL), but its functional role in this disease is poorly characterized. We therefore investigated the contribution of CD44 to CLL in a murine disease model, the Eµ-TCL1 transgenic mouse, and in CLL patients. Surface CD44 increased during murine CLL development. CD44 expression in human CLL was induced by stimulation with interleukin...

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PMID: 23547049
DOI: 10.1182/blood-2012-11-466250

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