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Article

Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model.

Blood - 5 Dec 2013

Lascano Valeria, Guadagnoli Marco, Schot Jan G, Luijks Dieuwertje M, Guikema Jeroen E J, Cameron Katherine, Hahne Michael, Pals Steven, Slinger Erik, Kipps Thomas J, van Oers Marinus H J, Eldering Eric, Medema Jan Paul, Kater Arnon P

Abstract excerpt

Although in vitro studies pointed to the tumor necrosis factor family member APRIL (a proliferation-inducing ligand) in mediating survival of chronic lymphocytic leukemia (CLL) cells, clear evidence for a role in leukemogenesis and progression in CLL is lacking. APRIL significantly prolonged in vitro survival of CD5(+)B220(dull) leukemic cells derived from the murine Eμ-TCL1-Tg (TCL1-Tg [transgenic]) model for...

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Identifiers

PMID: 24100449
DOI: 10.1182/blood-2013-04-497693
PMCID: PMC4123411

Genes

BCR

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