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Article

Role of BAFF and APRIL in human B‐cell chronic lymphocytic leukaemia

11 May 2006

Abstract excerpt

B-cell chronic lymphocytic leukaemia (B-CLL) is the most prevalent leukaemia in Western countries and is characterized by the gradual accumulation in patients of small mature B cells. Since the vast majority of tumoral cells are quiescent, the accumulation mostly results from deficient apoptosis rather than from acute proliferation. Although the phenomenon is relevant in vivo, B-CLL cells die rapidly in vitro as...

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PMID: 16827889
DOI: 10.1111/j.1365-2567.2006.02377.x

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