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Article

Cellular origin and pathophysiology of chronic lymphocytic leukemia.

The Journal of experimental medicine - 19 Nov 2012

Seifert Marc, Sellmann Ludger, Bloehdorn Johannes, Wein Frederik, Stilgenbauer Stephan, Dürig Jan, Küppers Ralf

Abstract excerpt

The cellular origin of chronic lymphocytic leukemia (CLL) is still debated, although this information is critical to understanding its pathogenesis. Transcriptome analyses of CLL and the main normal B cell subsets from human blood and spleen revealed that immunoglobulin variable region (IgV) gene unmutated CLL derives from unmutated mature CD5(+) B cells and mutated CLL derives from a distinct, previously...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23091163
DOI: 10.1084/jem.20120833
PMCID: PMC3501361

Genes

EBF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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