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Article

Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor

2 Nov 2012

Abstract excerpt

UNLABELLED: Survival of chronic lymphocytic leukemia (CLL) cells depends on stimuli provided by a suitable microenvironment. The factors and mechanisms providing this growth support for CLL cells are not fully understood. We found that plasma levels of macrophage migration inhibitory factor (MIF), a proinflammatory and immunoregulatory chemokine, were elevated in CLL patients. Therefore, we characterized the...

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PMID: 23118218
DOI: 10.1182/blood-2012-05-431452

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