Article

Loss of cohesin subunit Stag1 in zebrafish limits cell cycle progression and is compensated by altered BMP signalling and metabolic pathways

2026-08-21

Abstract excerpt

Cohesin is a large multisubunit protein complex that plays essential roles in cell proliferation, genome organisation, and gene regulation in metazoans. Germline mutations in cohesin subunits or regulators cause a group of human developmental disorders collectively known as cohesinopathies. Increasing evidence indicates that individual cohesin subunits can confer distinct molecular functions to the complex; for ex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47e38ef5-620d-5cf7-89c6-b132e0edda8c
DOI: 10.64898/2026.08.20.745648

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of cohesin subunit Stag1 in zebrafish limits cell cycle progression and is compensated by altered BMP signalling and metabolic pathwaysDOI 10.64898/2026.08.20.745648Read

Cohesin composition and dosage independently affect early development in zebrafish.Semantic proximity Read

Cohesin composition and dosage independently affect early development in zebrafishSemantic proximity Read

STAG2 cohesin is essential for heart morphogenesisSemantic proximity Read

The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integritySemantic proximity Read

Mutations in STAG2 cause an X-linked cohesinopathy associated with undergrowth, developmental delay, and dysmorphia: Expanding the phenotype in males.Semantic proximity Read

STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasmSemantic proximity Read

Cohesin mutations in myeloid malignancies made simple.Semantic proximity Read

Hardwired synthetic lethality within the cohesin complex in human cancer cellsSemantic proximity Read

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML.Semantic proximity Read

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AMLSemantic proximity Read

Chronic Loss of STAG2 Leads to Altered Chromatin Structure Contributing to DE-Regulated Transcription in AML.Semantic proximity Read

Cohesinopathies, gene expression, and chromatin organization.Semantic proximity Read