Article

Cohesin composition and dosage independently affect early development in zebrafish

2023-11-22

Abstract excerpt

Cohesin, a chromatin-associated protein complex with four core subunits (Smc1a, Smc3, Rad21 and either Stag1 or 2), has a central role in cell proliferation and gene expression in metazoans. Human developmental disorders termed “cohesinopathies” are characterised by germline mutations in cohesin or its regulators that do not entirely eliminate cohesin function. However, it is not clear if mutations in individual c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 039a0268-af19-506c-9b1f-c4ac2bef9cda
DOI: 10.1101/2023.11.21.568176

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cohesin composition and dosage independently affect early development in zebrafishDOI 10.1101/2023.11.21.568176Read

Cohesin composition and dosage independently affect early development in zebrafish.Semantic proximity Read

Loss of cohesin subunit Stag1 in zebrafish limits cell cycle progression and is compensated by altered BMP signalling and metabolic pathwaysSemantic proximity Read

Cohesin complex-associated holoprosencephalySemantic proximity Read

STAG2 cohesin is essential for heart morphogenesisSemantic proximity Read

How many roads lead to cohesinopathies?Semantic proximity Read

Mutations in STAG2 cause an X-linked cohesinopathy associated with undergrowth, developmental delay, and dysmorphia: Expanding the phenotype in males.Semantic proximity Read

RAD21 mutations cause a human cohesinopathy.Semantic proximity Read

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrumSemantic proximity Read

Cornelia de Lange syndrome, cohesin, and beyond.Semantic proximity Read

STAG2 promotes the myelination transcriptional program in oligodendrocytesSemantic proximity Read

Cohesinopathies, gene expression, and chromatin organization.Semantic proximity Read

Cohesin mutations in myeloid malignancies made simple.Semantic proximity Read