Article

Developing novel Lin28 inhibitors by computer aided drug design

2024-10-14

Abstract excerpt

<title>Abstract</title> <p>Lin28 is a key regulator of the cancer stem cell gene network that promotes therapy-resistant tumor progression in various tumors. However, no Lin28 inhibitor has been approved to treat cancer patients, urging the exploration of novel compounds as candidates to be tested for clinical trials. In this contribution, we applied computer-aided drug design (CADD) in combination with quantitat...

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Literature Corpus work: 47e35ec7-e4b0-56e4-a8aa-13750e253600
DOI: 10.21203/rs.3.rs-4644460/v1

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