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Article

Determinants of mRNA recognition and translation regulation by Lin28.

Nucleic acids research - 1 Apr 2012

Lei Xin-Xiang, Xu Jie, Ma Wei, Qiao Chong, Newman Martin A, Hammond Scott M, Huang Yingqun

Abstract excerpt

Lin28 is critical for stem cell maintenance and is also associated with advanced human malignancies. Our recent genome-wide studies mark Lin28 as a master post-transcriptional regulator of a subset of messenger RNAs important for cell growth and metabolism. However, the molecular basis underpinning the selective mRNA target regulation is unclear. Here, we provide evidence that Lin28 recognizes a unique motif in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22210884
DOI: 10.1093/nar/gkr1279
PMCID: PMC3333870

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