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Development of miRNA-based PROTACs targeting Lin28 for breast cancer therapy

18 Sept 2024

Abstract excerpt

Lin28, a highly conserved carcinogenic protein, plays an important role in the generation of cancer stem cells, contributing to the unfavorable prognosis of cancer patients. This RNA binding protein specifically binds to pri/pre-microRNA (miRNA) lethal-7 (let-7), impeding its miRNA maturation. The reduced expression of tumor suppressor miRNA let-7 fosters development and progression-related traits such as...

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PMID: 39292784
DOI: 10.1126/sciadv.adp0334

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