Article
An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates.
The Journal of biological chemistry - 17 Jul 2015
O'Day Elizabeth, Le Minh T N, Imai Shunsuke, Tan Shen Mynn, Kirchner Rory, Arthanari Haribabu, Hofmann Oliver, Wagner Gerhard, Lieberman Judy
Abstract excerpt
Lin28 is an evolutionarily conserved RNA-binding protein that inhibits processing of pre-let-7 microRNAs (miRNAs) and regulates translation of mRNAs that control developmental timing, pluripotency, metabolism, and tumorigenesis. The RNA features that mediate Lin28 binding to the terminal loops of let-7 pre-miRNAs and to Lin28-responsive elements (LREs) in mRNAs are not well defined. Here we show that Lin28 target...
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