Article

Identification of small molecule inhibitors against Lin28/let-7 to suppress tumor progression and its alleviation role in LIN28-dependent glucose metabolism

2024-01-02

Abstract excerpt

The reciprocal suppression of an RNA binding protein LIN28 (human abnormal cell lineage 28) and miRNA Let-7 (Lethal 7) is considered to have a prime role in hepatocellular carcinoma (HCC). Though targeting this inhibition interaction is effective for therapeutics, it causes other unfavorable effects on glucose metabolism and increased insulin resistance. Hence, this study aims to identify small molecules targeting...

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Literature Corpus work: 477fb247-2c5a-5c38-b36b-0258b5169ec2
DOI: 10.21203/rs.3.rs-3811675/v1

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