Article
Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28.
Nature structural & molecular biology - 11 Dec 2011
Loughlin Fionna E, Gebert Luca F R, Towbin Harry, Brunschweiger Andreas, Hall Jonathan, Allain Frédéric H-T
Abstract excerpt
Lin28 inhibits the biogenesis of let-7 miRNAs through a direct interaction with the terminal loop of pre-let-7. This interaction requires the zinc-knuckle domains of Lin28. We show that the zinc knuckle domains of Lin28 are sufficient to provide binding selectivity for pre-let-7 miRNAs and present the NMR structure of human Lin28 zinc knuckles bound to the short sequence 5'-AGGAGAU-3'. The structure reveals that...
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