Article

Quinoline-5,8-Dione CDC25 Inhibitors: Potent Anti-Cancer Agents in Leukemia and Patient-Derived Colorectal Organoids

2025-07-09

Abstract excerpt

<title>Abstract</title> <p>Cell division cycle 25 (CDC25) phosphatases have emerged as critical regulators of cell cycle progression and genomic stability, making them compelling therapeutic targets in oncology. Building on the established CDC25 inhibitor <bold>NSC663284</bold>, we strategically designed, synthesized, and evaluated a novel series of derivatives with diverse alkylamino side chains to enhance poten...

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Literature Corpus work: 3dbd8fb3-e973-5d85-8833-fad75456c142
DOI: 10.21203/rs.3.rs-6282946/v1

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