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In silico engineered multitarget-directed ligands for the polypharmaceutical treatment of PTEN loss of function endometrial adenocarcinoma

2026-08-31

Abstract excerpt

To combat refractory diseases, such as cancer, multitarget-directed ligands (MTDLs) have become an emerging area of research to exploit synthetic lethality (SL) relationships associated with drug resistance. Herein, we present the in silico design of MTDLs for the polypharmaceutical treatment of endometrial adenocarcinoma (EAC) and our discovery of a novel SL in EAC; PTEN loss of function (LOF) and the inhibition...

Identifiers and source

Literature Corpus work
c613f7e5-a678-57f2-a552-46e1162da8d5
DOI
10.64898/2026.08.28.747865
Open publication

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In silico engineered multitarget-directed ligands for the polypharmaceutical treatment of PTEN loss of function endometrial adenocarcinomaDOI 10.64898/2026.08.28.747865
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