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Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus

23 Jan 2020

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that follows an unpredictable disease course and affects multiple organs and tissues. We performed an integrated, multicohort analysis of 7,471 transcriptomic profiles from 40 independent studies to identify robust gene expression changes associated with SLE. We identified a 93-gene signature (SLE MetaSignature) that is differentially expressed in...

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PMID: 31971918
DOI: 10.1172/jci.insight.122312

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