Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

From Genes to Pathways: The Molecular Landscape of Systemic Lupus Erythematosus.

International journal of molecular sciences - 19 May 2026

Rashid Romana, Ramirez-Ortiz Zaida G

Abstract excerpt

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disorder arising from the convergence of genetic susceptibility, epigenetic remodeling, environmental exposures, and dysregulated immune networks. Although traditionally characterized by autoantibody production and immune complex mediated tissue injury, advances in genomics, systems immunology, and multi-omics profiling have revealed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenesis, Genetic
Share to Genetic Predisposition to Disease
Share to Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 42196527
DOI: 10.3390/ijms27104552
PMCID: PMC13207733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From Genes to Pathways: The Molecular Landscape of Systemic Lupus Erythematosus.PMID 42196527Read ↗

Recent insights into the role of innate immunity in lupusSemantic proximity Read ↗

New insights into the immunopathogenesis of systemic lupus erythematosus.Semantic proximity Read ↗

Transcriptomic analysis reveals immune signatures associated with specific cutaneous manifestations of lupus in systemic lupus erythematosusSemantic proximity Read ↗

Lupus Immune Complexes Drive Distinct Pro-Inflammatory Monocyte and Macrophage Populations Independent of Type I InterferonSemantic proximity Read ↗

Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants.Semantic proximity Read ↗

Recent insights into the genetic basis of systemic lupus erythematosus.Semantic proximity Read ↗

Monogenic systemic lupus erythematosus: insights in pathophysiology.Semantic proximity Read ↗

Systemic lupus erythematosus genetics: insights into pathogenesis and implications for therapy.Semantic proximity Read ↗

Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE)Semantic proximity Read ↗

Ancestry-based differences in the immune system are associated with lupus severitySemantic proximity Read ↗

Concepts in lupus pathophysiology: Lessons learned from disease across the spectrum.Semantic proximity Read ↗

A systems approach to renal inflammation in SLE.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.