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Succinate dehydrogenase A deficient renal cell carcinoma: A rare renal tumor distinct from typical Succinate dehydrogenase deficient renal cell carcinoma.

Pathology, research and practice - 1 Sept 2024

Liu Jiao, Wang Yuewei, Wang Xin, Li Yunxia, Jiang Yanxia, Li Yujun, Zhang Wei, Yu Wenjuan

Abstract excerpt

Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare subtype of RCC classified as a molecularly defined RCC in the fifth edition of the WHO. Most gene alterations in patients with SDH-deficient RCC involve the SDHB subunit, with less involvement of the SDHC, SDHA, and SDHD subunits. Four cases of SDHA-deficient RCC have been reported in the literature, of which one case was associated with...

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PMID: 39083879
DOI: 10.1016/j.prp.2024.155459

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