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Hypoxia-inducible factors drive miRNA-mediated downregulation of <i>L2HGDH</i> and <i>HIF1A</i> in clear cell renal cancer independent of 14q deletion

2024-12-04

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is characterized by pseudohypoxic signaling as well as metabolic and epigenetic aberrations of increasing severity during its pathogenesis and progression. Upon identifying that the markedly lower expression of L2HGDH and HIF1A in ccRCC tumors is not explained only by 14q deletion (⁓40% of ccRCC), we sought to elucidate the mechanisms underscoring their down-regulation ind...

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Literature Corpus work
0be6b388-02d3-5cd1-9126-21be7044eac1
DOI
10.1101/2024.12.01.625494
Open publication

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Hypoxia-inducible factors drive miRNA-mediated downregulation of <i>L2HGDH</i> and <i>HIF1A</i> in clear cell renal cancer independent of 14q deletionDOI 10.1101/2024.12.01.625494
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