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Genomic and Metabolic Hallmarks of SDH- and FH-deficient Renal Cell Carcinomas

11 Mar 2022

Abstract excerpt

BACKGROUND: Succinate dehydrogenase-deficient and fumarate hydratase-deficient renal cell carcinomas (SDHRCC and FHRCC) are rare kidney cancers driven by loss of TCA cycle enzymes. OBJECTIVE: To define and compare the genomic and metabolomic hallmarks of SDHRCC and FHRCC. DESIGN, SETTING, AND PARTICIPANTS: We analyzed SDHRCC and FHRCC tumors with either immunohistochemical evidence of loss of protein expression...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 35288096
DOI: 10.1016/j.euf.2021.12.002

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