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Article

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting Glycolysis

19 May 2021

Abstract excerpt

Metabolic reprogramming is the prominent feature of clear cell renal cell carcinoma (ccRCC). Succinate dehydrogenase subunit B (SDHB) is one of subunits of mitochondrial respiratory chain complex II. The loss of SDHB function is closely related with metabolic changes in kidney cancer cells. However, the role and molecular mechanism of SDHB in ccRCC occurrence and progression are still unclear. In this study, the...

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PMID: 34094922
DOI: 10.3389/fonc.2021.639408

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