Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1, 6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI / SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report

Abstract excerpt

Succinate dehydrogenase (SDH)-deficient renal cancer is a rare renal cancer subtype recently accepted by the World Health Organization as a unique subtype of renal cell carcinoma (RCC). Here we report a case of 17-year-old man. The detailed evaluation indicated occurrence of the SDHB-deficient RCC. The genetic testing revealed no germline mutation in SDH genes. Immunohistochemistry showed SDHB deficiency,...

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