Article

Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas

2021-06-09

Abstract excerpt

<h4>Purpose</h4> Succinate dehydrogenase-deficient and fumarate hydratase-deficient renal cell carcinomas (SDHRCC and FHRCC) are rare kidney cancers driven by loss of metabolically proximal enzymes. We sought to define and compare the genomic and metabolomic hallmarks of these entities. <h4>Experimental Design</h4> We analyzed SDHRCC and FHRCC tumors with either immunohistochemical evidence of loss of protein ex...

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Literature Corpus work: 9299d030-a471-53ec-ab9d-6155457d33a2
DOI: 10.1101/2021.06.09.445990

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