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Article

Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.

Genes - 15 Apr 2023

Chen Xi Richard, Shao Yongzhao, Sadowski Martin J, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative

Abstract excerpt

KLOTHO-VS heterozygosity (KL-VShet+) promotes longevity and protects against cognitive decline in aging. To determine whether KL-VShet+ mitigates Alzheimer's disease (AD) progression, we used longitudinal linear-mixed models to compare the rate of change in multiple cognitive measures in AD patients stratified by APOE ε4 carrier status. We aggregated data on 665 participants (208 KL-VShet-/ε4-, 307 KL-VShet-/ε4+,...

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PMID: 37107675
DOI: 10.3390/genes14040917
PMCID: PMC10137709

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Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.PMID 37107675Read ↗

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